Blood, Stem Cell and Cancer

The Blood, Stem Cell and Cancer Research Group undertakes translational research into bone marrow-derived stem cell and blood diseases. The group uses a ‘bench to bedside’ approach in which state-of-the-art cellular and molecular biology techniques are used to study the aetiology of blood, bone marrow and lymphatic disorders, with the goal of using this knowledge to develop new diagnostic and treatment strategies. blood drop

We engage in 4 key research themes: Stem Cell Biology, Stem Cell Transplantation, Haematological Cancers, and Thrombosis and Bleeding Disorders:

  • Our Stem Cell Biology Team uses adult pluripotent stem cells and gene editing technologies to define the genetic changes that lead to acute leukaemia. Identifying the genetic abnormalities that cause this leukaemia will us to invent novel targeted therapies for the disease.
  • The Stem Cell Transplantation Team investigates the immune changes that occur with stem cell transplantation in autoimmune disease patients. The acquired knowledge will enable us to discover new therapies to eliminate self-destructive cells and promote regeneration of normal immune system.
  • The Haematology Cancer Team studies how microRNAs lead to drug resistance in acute myeloid leukaemia with the goal to develop new tests and new therapy.
  • The Thrombosis and Haemostasis Team examines the importance of platelets in the formation of blood clots, and the clotting function of small vesicles called platelet-derived microparticles in cardiovascular disease and cancer.

The ultimate goal of our multidisciplinary collaborative research group is to fast-track our discoveries to improve the lives of our patients.

 

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