Professor Samuel BreitAs well as Research Program Head at St Vincent’s Centre of Applied Medical Research, Sam Breit is a Clinical Immunologist and Immunopathologist at St Vincent’s Hospital, Sydney and Professor of Medicine at University of New South Wales. The research activities of his Group are centred around the biology, role in disease pathogenesis and clinical application of two molecules that were first cloned and characterised by his laboratory in the 1990’s, on the basis of their increased expression with macrophage activation:

The TGF-b superfamily cytokine MIC-1/GDF15.

The intracellular chloride ion channel CLIC1.

Current Research Projects

  • The role of MIC-1/GDF15 in the biology of cancer
  • The mechanism of action of MIC-1/GDF15 in appetite regulation
  • The role of MIC-1/GDF15 in chronic inflammatory diseases
  • The mechanism of action of CLIC1 in control of chronic inflammatory processes
  • Structure/function of CLIC1

Opportunities for PhD and other higher degree research students
Prof Breit has a long track training record in training PhD and other research students. Positions are available for suitably qualified students to undertake laboratory based research within Prof Breit’s group. Such research would be focused around the group’s current project areas and would be negotiated on an individual basis.

Additional top-up funding is also often available for PhD students that already have a basic level of funding from Universities or other funding bodies. For enquiries, please see contact information, below.

Publications
View selected publications for MIC-1/GDF15 and CLIC1

PubMed publications for Professor Breit

External Funding Agencies
NHMRC
ARC
Cancer Council NSW
Prostate Cancer Foundation of Australia

Licensed discoveries

Measurement of serum levels of MIC-1/GDF15 for prognosis and management of cardiovascular diseases has been licensed to Hoffman La Roche.

MIC-1/GDF15 for treatment of obesity and chronic inflammatory diseases has been licensed to Novo Nordisk AG.

Licensing opportunities
Anti-MIC-1/GDF15 therapy for anorexia/cachexia of cancer and other diseases.

Measurement of serum levels of MIC-1/GDF15 for prognosis and management of cancer.

Current Laboratory Members
Lab Head

Samuel Breit

Postdoctoral Fellows
Lele Jiang
Yasmin Husaini
Vicky Wang-Wei Tsai
Liyun Wu

Research Assistants
Tamara Kuffner
Michelle Lee-Ng
Hui Li
Glen Lockwood
Ping Shang
Hong Ping Zhang

Graduate students
Kanin Salao
Xu Wei Luo

Administrative support
Anna Irvine

Contact Information
T: +61 (0)2 8382 4952
F: +61 (0)2 8382 4965
E: This email address is being protected from spambots. You need JavaScript enabled to view it.