Peter Duncan Neuroscience homepage Neurodegenerative Diseases Group HIV Neurosciences Group Clinical Trials Group

 

Neuroinflammation Group: Dr. Michael Lovelace, Ph.D, Dr. Gayathri Sundaram MVSc PhD, Varda Sardesai M. Phil.

Kynurenine pathway (KP) is the major pathway of the essential amino acid tryptophan metabolism. We have several projects to understand the role of this pathway in stem cell biology and neurogenesis, and how this relates to diseases like Multiple Sclerosis (MS) where the pathway is dysregulated and produces toxic metabolites capable of killing brain cells. 

 

Neuro2a

 

Our specific projects include:

  • Understanding KP signalling in adult stem cells and enhancing the brain’s regenerative capacity in neurodegenerative disorders like Multiple Sclerosis (MS).
  • Understanding how remyelination is repaired in MS as a basis for the development of future therapeutics targeting the KP.
  • Role of KP in circulating blood monocytes in progression of MS pathology.
  • Role of KP in Motor Neurone disease (MND) and how KP therapeutic inhibitors can help address the loss of brain cells in this disease

 


Selected Publications

  1. Lovelace MD, Varney B, Sundaram G, Franco NF, Ng ML, Pai S, Lim CK, Brew BJ. Current evidence for a role of the Kynurenine pathway of tryptophan metabolism in Multiple Sclerosis, Frontiers in Immunology 2016 Mar 246, doi: 10.3389/fimmu.2016.00246.
  2. Lovelace MD, Varney B, Sundaram G, Lennon MJ, Lim CK, Jacobs K, Guillemin GJ, Brew BJ. Recent evidence for an expanded role of the Kynurenine pathway of tryptophan metabolism in neurological diseases. Neuropharmcol 2016 Mar. In press. doi: 10.1016/j.neuropharm.
  3. Lennon M, Jones S, Lovelace M, Guillemin GJ, Brew B. Bcl11b: A new piece to the complex puzzle of amyotrophic lateral sclerosis neuropathogenesis? Neurotox Res 2015 Nov doi:0.1007/s12640-015-9573-5
  4. Jones SP, Franco N, Varney B, Sundaram G, Brown DA, de Bie J, Lim CK, Guillemin GJ, Brew BJ. Expression of the kynurenine pathway in human peripheral blood mononuclear cells: implications for inflammatory and neurodegenerative disease. PLoS One 2015 doi.org/10.1371/journal.pone.0131389
  5. Sundaram G, Brew B, Jones S, Lim C, Guillemin G. Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies. J Neuroinflam 2014 Dec 13;11 (1):204.

 

 

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