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HIV Neurosciences Group: Dr Lucette Cysique, Ph.D; Dr Kaz Suzuki, Ph.D; collaborator)

Research Fields:

  • Immunological, virological and neuro-inflammatory markers associated with HIV-associated Neurocognitive Disorders progression.
  • Neurocognitive functioning and its association with immunological and virological markers.
  • Brain macro-structure (MRI; DTI) and brain metabolism (MRS) and its association with immunological and virological markers. Neuroimaging performed in collaboration with Neuroscience Research Australia (NeuRA).
  • Brain aging in HIV-associated Neurocognitive Disorders.
  • Neurocognitive functioning and antiretroviral treatment.
  • Biomarkers of HIV latency in the Central Nervous System.

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Selected Publications:

  1. Bloch M, Kamminga J, Jayewardene A, Bailey M, Carberry A, Vincent T, Quan D, Maruff P, Brew B, Cysique LA. A Screening Strategy for Hiv-Associated Neurocognitive Disorders (HAND) that Accurately Identifies Patients Requiring Neurological Review. Clin Infect Dis. 2016 Sep 1;63(5):687-93. doi: 10.1093/cid/ciw399
  2. Mayo NE, Brouillette M-J, Fellows LK, and Positive Brain Health Now Investigators. Understanding and optimizing brain health in HIV now: protocol for a longitudinal cohort study with multiple randomized controlled trials. BMC Neurol. 2016 Jan 14;16:8. doi: 10.1186/s12883-016-0527-1.
  3. Churchill M, Gray L, Cowley D, Welsh C, Lu H, Brew B, Lewin S, Wesselingh S, Gorry P. CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency reversing agents with implications for cure strategies. Molecular Psychiatry (2016) 21, 574–584; doi:10.1038/mp.2015.111; published online 25 August 2015
  4. Cysique LA, Hey-Cunningham WJ, Dermody N, Chan P, Brew BJ, Koelsch KK. Peripheral blood mononuclear cells’ HIV DNA reservoir size impacts intermittently on neurocognition in long-term suppressed HIV-infected adults. PLoS One 2015;10(4):e0120488.

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